Volume 18, Issue 4 (2-2024)
MGj 2024, 18(4): 367-376 |
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fayazi J, shariat M, neysi S. Investigating the Interactions Between Protoporphyrin IX (HEM) and Flavin Mononucleotide (FMN) in the Cytochrome B Respiratory Chain of Sheep. MGj 2024; 18 (4) : 2
URL: http://mg.genetics.ir/article-1-1817-en.html
URL: http://mg.genetics.ir/article-1-1817-en.html
Agricultural Sciences and Natural Resources University of Khuzestan
Abstract: (751 Views)
Cytochrome B plays a role in the electron transport chain, and as this gene leads to energy production in animals and increases efficiency, identifying the most effective factors on this gene and comparing the best applicable ligands in the electron transfer pathway can improve animal production and facilitate genetic studies. In this study, the interactions of protoheme and flavin mononucleotide in combination with cytochrome B were simulated using molecular docking to select the most effective ligand in electron transfer by comparing two practical ligands. The results of molecular docking and analysis using online servers showed that protoheme has the highest number of amino acids involved in electrostatic and hydrophobic interactions compared to flavin mononucleotide. Based on the obtained results of molecular docking, protoheme had the best binding energy and the best pose with the most negative energy and the largest number, indicating the best ligand-protein complex binding, compared to flavin mononucleotide, and it can be said that the higher number of interactions and bonds formed by the combination of protoheme with cytochrome B can confirm this claim. Arginine has a high positive charge and may have contributed to the formation of hydrogen bonds that may have increased electrostatic interactions in combining protoheme with cytochrome B. The cytochrome B protein-protein interaction network was predicted based on mitochondrial proteins, and 10 proteins with high potential node degree scores were identified.
Article number: 2
Type of Study: Applicable |
Subject:
Subject 02
Received: 2023/04/22 | Accepted: 2024/02/28 | Published: 2024/03/4
Received: 2023/04/22 | Accepted: 2024/02/28 | Published: 2024/03/4
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