%0 Journal Article %A الهام رضوان نژاد, %A مجتبی مرتضوی, %A علی ریاحی مدواری, %T Software modeling of heat-shock protein 70 (HSP70) of poultry %J Modern Genetics Journal %V 11 %N 2 %U http://mg.genetics.ir/article-1-1416-en.html %R %D 2016 %K Chaperon, Heat stress, HSP70, Modeling, Poultry, %X Heat shock proteins (HSPs) are the most of intracellular proteins. Their synthesis is rapidly up-regulated because of various ‘stressors’ including temperature, glucose deprivation, and infection. These proteins play an important role in survival cell and intracellular homeostasis under stress conditions. Since the crystallographic structure of the protein extensively damaged from heat stress it is not reported in poultry, modeling the structure of HSP70 of poultry can identify the mechanism of action of this protein against environmental stresses and help to reduce costs related to environmental stresses. In this study three-dimensional structure of protein HSP70 in poultry, species Gallus gallus was modeling to identify structural domains and specific position in this structure. The three-dimensional model was prepared by homology modeling using I-TASSER and Swiss Model with similar and suitable pattern from database PBD (Homo sapiens HSP70, Bovine HSC70). In order to evaluate and analysis of structure model SPDBV software was used. Quality evaluation of the model was done based on the structural parameters of C-score, TM-score and RMSD that Showed the quality of the proposed model is suitable and stable for HSP70 of poultry. Modeling HSP70 in poultry is the first stage in identifying of protein's structure of this chaperon. Due to the high similarity of the amino acid sequence of this Chaperon with determined structural Chaperons, this model can high reliability be used in later analysis and design. %> http://mg.genetics.ir/article-1-1416-en.pdf %P 173-183 %& 173 %! %9 %L A-10-109-416 %+ %G eng %@ 2008-4439 %[ 2016